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Target List
Independent Pharmacy by State

230+ Pharmacies for sale in South DakotaOff-market acquisition targets

230+ acquisition-ready pharmacies mapped in South Dakota.

Who this page is for. Buyers sourcing off-market pharmacies in South Dakota.

Companies
230+

Updated Jun 6, 2026. See your match on a free live map.

230+
Companies
Free
For buyers
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What we hold on independent pharmacy in South Dakota

We can map this market. We cannot hand you its contacts.

The owner is named on 15% of the companies we hold here, and named with a way to reach them on 5%. We will not sell you a contact pack this thin. If you want this market worked properly it is a sourcing engagement, and the first step is a conversation.

A sourcing mandate is a fixed fee, scoped on the call, delivered in 10 days, and we build and enrich the shortlist for you. The call decides whether it is worth running.

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Independent Pharmacy data sources

South Dakota pharmacy businesses are sourced from OpenStreetMap records, SBA loan registry data, and state business license filings where available. Each of the 230 mapped companies is scored using years in operation where known, customer review signals, and estimated revenue to produce the Acquisition Fit Score used to rank targets. Request the map, then book a 30-minute target review to rank the top 10 and scope how we reach them.

South Dakota's independent pharmacy sector represents a stable acquisition opportunity within a business-friendly regulatory environment and a healthcare-focused state economy. With 230+ independent pharmacy businesses currently mapped across the state, the market reflects South Dakota's commitment to community-based healthcare delivery and rural pharmacy access. The state's favorable tax structure and minimal regulatory burden create an attractive backdrop for pharmacy operators, while the region's aging population and dispersed rural communities ensure consistent demand for local pharmaceutical services. This combination of market fundamentals and operational conditions has positioned South Dakota as a meaningful territory for acquirers seeking to expand pharmacy networks in underserved areas. This ownership profile suggests well-developed operational systems, established customer relationships, and documented financial performance, all of which reduce acquisition risk and integration complexity. For acquirers, the state's 230+ independent pharmacies present a fragmented but accessible market where consolidation can drive operational efficiencies, leverage purchasing power, and preserve community healthcare access.

Ownership intelligence

Serava maps and scores all 230 pharmacies in South Dakota by years in business, fit, and exit signals. The full ranked list and fit scores unlock inside your deal map.

South Dakota has 230 mapped pharmacy targets distributed across multiple markets, including Hot Springs, Mission, North Sioux City, Corsica, Spearfish.

Top 6 South Dakota pharmacy targets

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FALL R...

Hot Springs, South Dakota$5.5M to $8.2M est. revenue
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BURKE C...

Mission, South Dakota$1.2M to $1.8M est. revenue
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DUNES F...

North Sioux City, South Dakota$2.1M to $3.2M est. revenue
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DOUGLAS C...

Corsica, South Dakota$3M to $4.6M est. revenue
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Full ranked list and fit scores unlock from the target-list request above

SAFEWAY I...

Spearfish, South Dakota$2.1M to $3.2M est. revenue
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Full ranked list and fit scores unlock from the target-list request above

BURKE C...

Presho, South Dakota$3.6M to $5.5M est. revenue
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Unlock all 230 pharmacies

Ranked target map, websites, fit-score rationale, and shortlist export. This vertical has no owner-contact layer, so reaching owners is a sourcing engagement rather than an export.

Request the target list from the primary CTA above.

Frequently Asked Questions

How many pharmacies are for sale in South Dakota?

Serava.AI has mapped 230 acquisition-ready pharmacies in South Dakota. The primary market is Sioux Falls with 45 mapped companies. These are active, operating businesses with a minimum of 5 years in business, scored for owner exit readiness and financial profile. Not all are actively listed for sale: the majority are off-market targets that have not yet engaged a broker.

What is the typical revenue of a pharmacy in South Dakota?

Revenue for pharmacies in South Dakota varies by size, but most SMB-scale targets in our database fall in the $1M to $15M annual revenue range. Serava.AI provides revenue estimates benchmarked from payroll data, OSM business data, and SBA loan records.

What should I look for when buying a pharmacy?

Key signals for a high-quality pharmacy acquisition include: a long operating history (15+ years in business), stable recurring or repeat revenue, strong online ratings (4.0+ with 20+ reviews), an established local customer base, and a skilled technical workforce. Serava.AI's Acquisition Fit Score (0 to 100) weighs all of these factors and benchmarks each company against your specific buyer criteria.

How do I find off-market pharmacies in South Dakota?

Many pharmacy business acquisitions start with off-market research before an owner runs a brokered process. Serava.AI maps pharmacy companies in South Dakota using years in business and local market data, then helps qualified buyers prioritize outreach with available contact-signal coverage.

What is the typical asking price for a pharmacy in South Dakota?

Pharmacies in South Dakota typically trade at 3x to 6x EBITDA, depending on revenue concentration, customer contracts, and owner dependency. A business with $2M revenue and 12% EBITDA margins ($240k EBITDA) would price between $720k and $1.44M. Businesses with recurring contracts, a long operating history, and clean books command higher multiples.

Which areas in South Dakota have pharmacies available for acquisition?

South Dakota's 230 mapped pharmacy targets are spread across multiple markets. Active areas in the Serava.AI database include Hot Springs, Mission, North Sioux City, Corsica, Spearfish. Because the pharmacy market in South Dakota is distributed across many smaller cities rather than concentrated in a few metros, buyers searching this state will find targets across a wide geographic range. Serava.AI scores and ranks all targets by acquisition fit regardless of city size.

Top cities for pharmacy acquisitions in South Dakota

Sioux Falls45 companies

About this data

Serava.AI maps pharmacy acquisition targets in South Dakota from OpenStreetMap records, Companies House (UK), SBA loan registry data, and state business license filings. The 230 mapped companies are each scored 0 to 100 on acquisition fit using years in business, customer review ratings, and estimated revenue. Scores above 80 represent high-priority outreach targets with strong succession signals. Data is refreshed regularly via our automated scraping pipeline.

Top Cities in South Dakota

Sioux Falls45

Province Guides

How to buy a pharmacyPharmacy for sale in Arizona checklistSearch fund deal sourcing guide

Independent Pharmacy in Other Regions

California479,643Texas156,392Florida142,000New York118,000Illinois86,000Pennsylvania79,000

How this data is sourced

Serava maps 230 independent pharmacy businesses in South Dakota from public registries, licensing boards, and corporate filings. We filter out chains, nonprofits, and the inactive records we can detect, but some listings may still be inactive or mis-tagged.

Each is scored 0 to 100 on years in business, succession signals, and contact reachability, so the result is a ranked set of owner-led targets that are not posted on any marketplace.

Built and maintained by Serava, founder Sadra Khorvash. Last updated October 2026.

Other Industries in South Dakota

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Independent Pharmacy acquisition targets in South Dakota

See how many owner-led independent pharmacy businesses in South Dakota match your thesis, free.

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Owner-direct contacts are thin in this market: we hold a named owner and a way to reach them on the same record for 5% of the companies here. Pro here includes 20 owners a month, researched by hand from your own map: the owner's name and the business phone, each with the public page it came from, within 3 business days. An owner we cannot find does not count toward the 20.

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